Raw material selection
Ribobay has a perfect quality system and strictly
follows the "Good Manufacturing Practice" in the procurement of raw and auxiliary materials,classifies incoming materials and sets quality standards.
We test and release the materials to ensure their quality,such as solid-phase support, nucleoside phosphoramidites, anhydrous acetonitrile and other chemical raw materials.
We audits the qualification of suppliers in strict accordance with the supplier audit management procedures,ensuring the quality of supply materials and the stability of supply channels.
Production process development and validation
The process development team of Ribobay possess industry-leading oligonucleotide process development and production service capabilities, have rich experience in analysis of key process control points for oligonucleotides, research on process impurities, quality control, and production scaling up. We can help customers to complete process development, validation and process transfer, and provide final process summary reports.
We have world-class research, development and manufacturing facilities, advanced synthesis processes, offering comprehensive purification solutions consisting of tangential flow filtration, multiple chromatographic fillers.
Scale-up and consistency in manufacturing can be achieved, as well as great flexibility that remove various impurities generated during the preparation of oligonucleotides effectively. Ribobay is a good supplier of commercial oligonucleotides.
Process of Chemical Modification and Conjugation
● Backbone modifications (Phosphate modification, Sugar-phosphate modification)
● Sugar modifications (2'-OMe，2'-F，2'-O-MOE，LNA, cET, ENA)
● Base modifications (5-Methylcytosine)
● Conjugates (GalNac, PEG, Cholesterol)
